| Identification | Back Directory | [Name]
H-LYS-D-PRO-THR-OH | [CAS]
117027-34-6 | [Synonyms]
LYS-D-PRO-THR
L-LYS-D-PRO-L-THR
H-LYS-D-PRO-THR-OH
interleukin1beta(193-195
INTERLEUKIN 1B ANTAGONIST
L-LYSYL-D-PROLYL-L-THREONINE
L-Threonine, L-lysyl-D-prolyl-
(D-Pro194)-IL-1β (193-195) (human)
(D-PRO194)-IL-1B (193-195) (HUMAN)
(D-PRO194)-IL-1BETA (193-195) (HUMAN)
(D-PRO194)-INTERLEUKIN-1B (193-195) (HUMAN)
(D-Pro194)-Interleukin-1β (193-195) (human)
(D-Pro194)-Interleukin-1β (193-195) (human)
(D-PRO194)-INTERLEUKIN-1BETA (193-195) (HUMAN)
(D-Pro194)-Interleukin-1b (193-195) (huMan), LDPT
2-[[[1-(2,6-diamino-1-oxohexyl)-2-pyrrolidinyl]-oxomethyl]amino]-3-hydroxybutanoic acid
(2S,3R)-2-((R)-1-((S)-2,6-Diaminohexanoyl)pyrrolidine-2-carboxamido)-3-hydroxybutanoic acid | [Molecular Formula]
C15H28N4O5 | [MDL Number]
MFCD00076555 | [MOL File]
117027-34-6.mol | [Molecular Weight]
344.41 |
| Hazard Information | Back Directory | [Uses]
Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2]. | [in vivo]
Lys-D-Pro-Thr (10 mg/kg; IP; for 4 days) inhibits the protective effect of fMLP (HY-P0224) and that of MMK-1 (HY-P1117) against Etoposide (HY-13629)-induced alopecia[1].
| Animal Model: | 11-d-old rats[1] | | Dosage: | 10 mg/kg | | Administration: | IP; for 4 days | | Result: | Inhibited the protective effect of fMLP and that of MMK-1 against Etoposide-induced alopecia. It alone did not induce alopecia.
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| [IC 50]
IL-1 | [References]
[1] Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202. DOI:10.1271/bbb.60656
[2] Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11. DOI:10.1016/0143-4179(91)90067-s |
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