| Identification | Back Directory | [Name]
3-(pyridin-2-ylsulfonyl)-N-(4-(trifluoroMethyl)phenyl)-8-azabicyclo[3.2.1]octane-8-carboxaMide | [CAS]
1170321-92-2 | [Synonyms]
3-(pyridin-2-ylsulfonyl)-N-(4-(trifluoroMethyl)phenyl)-8-azabicyclo[3.2.1]octane-8-carboxaMide
3-(Pyridin-2-ylsulfonyl)-N-(4-(trifluoromethyl)phenyl)-8-azabicyclo[3.2.1]octane-8-carboxamide-endo
8-Azabicyclo[3.2.1]octane-8-carboxamide, 3-(2-pyridinylsulfonyl)-N-[4-(trifluoromethyl)phenyl]-, (3-endo)- | [Molecular Formula]
C20H20F3N3O3S | [MDL Number]
MFCD22419483 | [MOL File]
1170321-92-2.mol | [Molecular Weight]
439.45 |
| Hazard Information | Back Directory | [Uses]
ELOVL6-IN-4 is a potent, selective, and orally active long chain fatty acid elongase 6 (ELOVL6) inhibitor with IC50s of 79 nM and 94 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-4 shows excellent selectivity over the other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3[1]. | [in vivo]
ELOVL6-IN-4 (compound 1w; 1-10 mg/kg; oral administration; once) potently and dose-dependently suppresses the elongation index in the liver in mice[1]. | Animal Model: | Male C57BL/6J mice[1] | | Dosage: | 1 mg/kg, 3 mg/kg, and 10 mg/kg | | Administration: | Oral administration; once | | Result: | Potently and dose-dependently suppressed the elongation index in the liver in mice.
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| [References]
[1] Tsuyoshi Nagase, et al. Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009 Jul 23;52(14):4111-4. DOI:10.1021/jm900488k |
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| Company Name: |
Matrix Scientific
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803 788-9494 All other calls |
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www.matrixscientific.com |
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