| Identification | Back Directory | [Name]
licopyranocoumarin | [CAS]
117038-80-9 | [Synonyms]
licopyranocoumarin
3-(2,4-Dihydroxyphenyl)-8-(hydroxymethyl)-5-methoxy-8-methyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one
(+)-3-(2,4-Dihydroxyphenyl)-8-(hydroxymethyl)-6,7-dihydro-8-methyl-5-methoxy-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one | [Molecular Formula]
C21H20O7 | [MOL File]
117038-80-9.mol | [Molecular Weight]
384.38 |
| Hazard Information | Back Directory | [Uses]
Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1]. | [Definition]
ChEBI: Licopyranocoumarin is an isoflavonoid and an organic hydroxy compound. | [IC 50]
CYP3A4: 32 μM (IC50) | [References]
[1] Takahiro Fujimaki, et al. Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. PLoS One. 2014 Jun 24;9(6):e100395. DOI:10.1371/journal.pone.0100395
[2] Sachiko Tsukamoto, et al. CYP3A4 inhibitors isolated from Licorice. Biol Pharm Bull. 2005 Oct;28(10):2000-2. DOI:10.1248/bpb.28.2000 |
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