| Identification | Back Directory | [Name]
HO-3867 | [CAS]
1172133-28-6 | [Synonyms]
HO-3867
CS-2205
HO-3868
HO-3867
(HO 3867
HO-3867 USP/EP/BP
inhibit,Inhibitor,Apoptosis,STAT,HO 3867,HO-3867
(3E,5E)-3,5-Bis(4-fluorobenzylidene)-1-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-4-piperidinone
1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-(3E,5E)-4-piperidinone
(3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone
4-Piperidinone, 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-, (3E,5E)- | [Molecular Formula]
C28H30F2N2O2 | [MOL File]
1172133-28-6.mol | [Molecular Weight]
464.55 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥18.15 mg/mL in DMSO | [form ]
solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor activity. | [IC 50]
STAT3 | [References]
[1] Rath KS et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74(8):2316-27. DOI:10.1158/0008-5472.CAN-13-2433
[2] Hu Y, et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017 Apr;28(4):392-400. DOI:10.1097/CAD.0000000000000470
[3] Tierney BJ et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol Ther. 2012 Jul;13(9):766-75 DOI:10.4161/cbt.20559 |
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