| Identification | Back Directory | [Name]
RAC ALBUTEROL-D9 | [CAS]
1173021-73-2 | [Synonyms]
Salbutamol-d9
RAC ALBUTEROL-D9
[2H9]-rac Albuterol
[2H9]- (±)-Albuterol
(±)-Albuterol-d9 (tert-butyl-d9)
Albuterol-(tert-butyl-d9) acetate
Salbutamol-(tert-butyl-d9) acetate
Salbutamol-(tert-butyl-d9) acetate salt
SalbutaMol-D9 acetate(Albuterol-D9 acetate)
α1-[[(1,1-DiMethylethyl)aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol-d9
a1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol-d9
(±)-2-(tert-Butyl-d9-amino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanol acetate salt
4-[2-[[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol | [Molecular Formula]
C13H21NO3 | [MDL Number]
MFCD26142896 | [MOL File]
1173021-73-2.mol | [Molecular Weight]
239.311 |
| Chemical Properties | Back Directory | [Melting point ]
142-146°C | [storage temp. ]
-20°C Freezer | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
neat | [color ]
White to Yellow |
| Hazard Information | Back Directory | [Description]
Salbutamol-d9 is intended for use as an internal standard for the quantification of salbutamol (Item Nos. 21003 | 23991) by GC- or LC-MS. Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor). It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs. It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg). Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
A labeled ?-adrenoceptor agonist | [Uses]
A labelled β2-adrenoceptor agonist. Bronchodilator; tocolytic. | [Uses]
RAC ALBUTEROL-D9 is a labelled β2-adrenoceptor agonist,it is intended for use as an internal standard for the quantification of Albuterol by GC- or LC-mass spectrometry.
| [storage]
Store at -20°C | [References]
[1] CHRISTOPHER KERN. Synthesis and Pharmacological Characterization of β2-Adrenergic Agonist Enantiomers: Zilpaterol[J]. Journal of Medicinal Chemistry, 2009, 52 6: 1773-1777. DOI: 10.1021/jm801211c
[2] BAKER J G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors[J]. British Journal of Pharmacology, 2009, 144 3: 317-322. DOI: 10.1038/sj.bjp.0706048
[3] VALERIE A. CULLUM. Salbutamol: a new, selective β-adrenoceptive receptor stimulant[J]. British Journal of Pharmacology, 1969, 35 1: 141-151. DOI: 10.1111/j.1476-5381.1969.tb07975.x
[4] M.G. ARROYO. Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction[J]. Journal of Veterinary Internal Medicine, 2016, 30 4: 1333-1337. DOI: 10.1111/jvim.14320 |
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