| Identification | Back Directory | [Name]
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 | [CAS]
1173021-86-7 | [Synonyms]
EOS-60378
2-Ketoglutaric acid-d6
α-Ketoglutaric acid-d6
α-Ketopentanoic acid-d6
2-Ketopentanedioic acid-d6
ALPHA-KETOGLUTARIC ACID (D6, 98%)
2-oxopentanedioic-3,3,4,4-d4acid-d2
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 | [Molecular Formula]
C5D6O5 | [MDL Number]
MFCD00190469 | [MOL File]
1173021-86-7.mol | [Molecular Weight]
152.135 |
| Chemical Properties | Back Directory | [Melting point ]
114-117 °C | [form ]
Solid | [color ]
White to off-white | [InChI]
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/i1D2,2D2/hD2 | [InChIKey]
KPGXRSRHYNQIFN-DTDGFSOZSA-N | [SMILES]
[2H]OC(=O)C(=O)C([2H])([2H])C([2H])([2H])C(=O)O[2H] | [CAS Number Unlabeled]
328-50-7 |
| Hazard Information | Back Directory | [Uses]
2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. DOI:10.1128/MMBR.00038-15
[3] Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662. DOI:10.1016/j.ijbiomac.2016.12.015 |
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