| Identification | Back Directory | [Name]
BRL 15572 hydrochloride | [CAS]
1173022-77-9 | [Synonyms]
CS-1063
BRL-15572; BRL15572 ; BRL 15572 DIHYDROCHLORIDE; BRL15572 DIHYDROCHLORIDE | [Molecular Formula]
C25H28Cl2N2O | [MDL Number]
MFCD09878288 | [MOL File]
1173022-77-9.mol | [Molecular Weight]
443.41 |
| Hazard Information | Back Directory | [Uses]
BRL 15572 Hydrochloride is an analog of BRL 15572, which is a preferential antagonist at native human 5-HT1D receptors. | [Definition]
ChEBI: 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride is a hydrochloride that is the monohydrochloride salt of 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types. It has a role as a serotonergic antagonist and a prodrug. It contains a 4-(3-chlorophenyl)-1-(2-hydroxy-3,3-diphenylpropyl)piperazin-1-ium(1+). | [in vivo]
BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3]. | [IC 50]
5-HT1D Receptor | [storage]
+4°C (desiccate) |
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