| Identification | Back Directory | [Name]
ETHYL 2-AMINO-4-FLUOROBENZOATE | [CAS]
117324-05-7 | [Synonyms]
Ethyl 2-ami-4-fluorobenzoate
ETHYL 2-AMINO-4-FLUOROBENZOATE
-amino-4-fluoro-benzoic acid ethyl ester
Benzoic acid, 2-amino-4-fluoro-, ethyl ester | [Molecular Formula]
C9H10FNO2 | [MDL Number]
MFCD08275015 | [MOL File]
117324-05-7.mol | [Molecular Weight]
183.18 |
| Chemical Properties | Back Directory | [Boiling point ]
271.2±20.0 °C(Predicted) | [density ]
1.218±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
1.46±0.10(Predicted) | [Appearance]
Light yellow to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
A. Synthesis of ethyl 2-amino-4-fluorobenzoate
2-Amino-4-fluorobenzoic acid (1.57 g, 10.1 mmol) was dissolved in anhydrous ethanol (20 mL) and cooled to low temperature. Pure thionyl chloride (4.4 mL, 60 mmol) was added slowly and the reaction mixture was refluxed for 4 days. Subsequently, thionyl chloride (8 mL, 110 mmol) was added supplementally and the mixture was concentrated after the reaction was completed. It was diluted with ethyl acetate (EtOAc), washed with 2N sodium hydroxide (NaOH) solution, dried and concentrated in vacuum to give ethyl 2-amino-4-fluorobenzoate (1.73 g, 94% yield). | [References]
[1] Patent: US2002/77486, 2002, A1
[2] Patent: US6906063, 2005, B2
[3] Patent: EP1380576, 2004, A1. Location in patent: Page 97 |
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