| Identification | Back Directory | [Name]
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID | [CAS]
117391-49-8 | [Synonyms]
RARECHEM AK HC T305
3-AMINO-3-(2-FLUOROPHENYL)PROPANOIC ACID
β-amino-β-(2-fluorophenyl)propionic acid
Benzenepropanoic acid, β-amino-2-fluoro-
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
3-Amino-3-(2-fluorophenyl)propanoicacid95%
DL-3-Amino-3-(2-fluorophenyl)propanoic acid
DL-3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
(RS)-3-Amino-3-(2-fluorophenyl)-propionic acid
3-amino-3-(2-fluorophenyl)propanoic acid(SALTDATA: FREE) | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C9H10FNO2 | [MDL Number]
MFCD00193241 | [MOL File]
117391-49-8.mol | [Molecular Weight]
183.18 |
| Chemical Properties | Back Directory | [Melting point ]
222-224 | [Boiling point ]
302.6±32.0 °C(Predicted) | [density ]
1.289±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
3.67±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: Malonic acid (1.04 g, 10 mmol) and ammonium formate (1.26 g, 20 mmol) were dissolved in ethanol (50 mL), followed by the addition of 2-fluorobenzaldehyde (10 mmol). The reaction mixture was heated to reflux for 7 hours. After completion of the reaction, it was cooled to room temperature and the crude product was collected by filtration. The crude product was purified by recrystallization (using 95% ethanol as a solvent) to give 3-amino-3-(2-fluorophenyl)propionic acid as a final white solid. | [References]
[1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 402 - 418
[2] Advanced Synthesis and Catalysis, 2010, vol. 352, # 2-3, p. 395 - 406
[3] Advanced Synthesis and Catalysis, 2017, vol. 359, # 9, p. 1570 - 1576
[4] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 11, p. 1207 - 1212
[5] Journal of Organic Chemistry, 2009, vol. 74, # 23, p. 9152 - 9157 |
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