| Identification | Back Directory | [Name]
5-(trifluoroMethyl)pyrazine-2-carboxylic acid | [CAS]
1174321-06-2 | [Synonyms]
180624
5-Difluoromethylpyrazine-2-carboxylic acid
5-(trifluoroMethyl)pyrazine-2-carboxylic acid
2-Pyrazinecarboxylic acid, 5-(difluoromethyl)- | [Molecular Formula]
C6H4F2N2O2 | [MDL Number]
MFCD20640530 | [MOL File]
1174321-06-2.mol | [Molecular Weight]
174.1 |
| Chemical Properties | Back Directory | [Boiling point ]
319.8±42.0 °C(Predicted) | [density ]
1.496±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
2.59±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
A3-5 (1.5 g, 6.5 mmol) was dissolved in dichloromethane (DCM, 20 mL) at 0 °C and trifluoroacetic acid (TFA, 2 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford the product A3-6 (1 g, 88% yield). The structure of the product was confirmed by 1H NMR (400 MHz, MeOD): δ 9.30 (s, 1H), 8.98 (s, 1H), 6.92 (t, J = 14.4 Hz, 1H). | [References]
[1] Patent: WO2012/138734, 2012, A1. Location in patent: Page/Page column 65-66
[2] Patent: US2009/209755, 2009, A1. Location in patent: Page/Page column 54-55
[3] Patent: US2010/93999, 2010, A1. Location in patent: Page/Page column 49
[4] Patent: WO2011/9897, 2011, A1. Location in patent: Page/Page column 74; 76
[5] Patent: WO2011/9898, 2011, A1. Location in patent: Page/Page column 86; 87 |
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