| Identification | Back Directory | [Name]
1(2H)-Pyridinecarboxamide, 4-[6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro- | [CAS]
1175296-94-2 | [Synonyms]
OSI296
OSI-296
OSI 296
1(2H)-Pyridinecarboxamide, 4-[6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro- | [Molecular Formula]
C21H19Cl2FN4O3 | [MOL File]
1175296-94-2.mol | [Molecular Weight]
465.3 |
| Hazard Information | Back Directory | [Description]
OSI-296 is a potent and dual inhibitor of cMET and RON kinases with IC50 for cMet = 42 nM and IC50 for sfRon = 200 nM. OSI-206 shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated. OSI-296 also reduced tumour growth in the bone. | [Uses]
OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated[1]. | [References]
[1] Steinig AG, et al. Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases. Bioorg Med Chem Lett. 2013;23(15):4381-4387. DOI:10.1016/j.bmcl.2013.05.074 |
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