| Identification | Back Directory | [Name]
AM-211 | [CAS]
1175526-27-8 | [Synonyms]
AM-211
AM211 free acid
OPXIRFWNLBDKQB-UHFFFAOYSA-N
AM211 (Synonyms: AM211 free acid)
inhibit,AM211,Inhibitor,Prostaglandin Receptor,AM 211,AM-211
[1,1'-Biphenyl]-3-acetic acid, 2'-[[ethyl[[(phenylmethyl)amino]carbonyl]amino]methyl]-6-methoxy-4'-(trifluoromethyl)- | [Molecular Formula]
C27H27F3N2O4 | [MDL Number]
MFCD22124468 | [MOL File]
1175526-27-8.mol | [Molecular Weight]
500.51 |
| Chemical Properties | Back Directory | [Boiling point ]
656.4±55.0 °C(Predicted) | [density ]
1.264±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (249.75 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
4.38±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. | [in vivo]
AM211 (1, 10, and 30 mg/kg, p.o.) dose-dependently decreases in the number of DK-PGD2-induced peripheral blood leukocytes, with a calculated ED50 of 0.85 mg/kg. AM211 (30 mg/kg) also decreases antigen-induced pulmonary inflammation in guinea pigs. AM211 (10 mg/kg, p.o.) causes significant decrease in ovalbumin (OVA)-induced sneezing in a mouse model of allergic rhinitis[1]. | [References]
[1] Bain G, et al. Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301. DOI:10.1124/jpet.111.180430 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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