| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy- | [CAS]
1176-88-1 | [Synonyms]
5-OH-HxMF
5 OH HxMF,5OHHxMF
4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy- | [Molecular Formula]
C21H22O9 | [MDL Number]
MFCD29059584 | [MOL File]
1176-88-1.mol | [Molecular Weight]
418.394 |
| Hazard Information | Back Directory | [Uses]
5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities[1][2][3]. | [Definition]
ChEBI: 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone is a member of flavonoids and an ether. | [in vivo]
5-OH-HxMF (topically treated; twice a week; for 20 weeks; 1 and 3 μmol in 200 μL acetone) is an effective antitumor agent and its inhibitory effect is through the down-regulation of inflammatory iNOS and COX-2 gene expression in mouse skin[3]. | Animal Model: | Female ICR mice treated with 12-O-tetradecanoylphorbol-13-acetate (TPA)[3]. | | Dosage: | 1 and 3 μmol in 200 μL acetone | | Administration: | Topically treated; twice a week; for 20 weeks | | Result: | Significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory parameters. |
| [References]
[1] Hui-Chi Lai, et al. Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. PLoS One. 2011;6(11):e28280. DOI:10.1371/journal.pone.0028280
[2] Min Jeong Kim, et al. Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage. Mol Med Rep. 2014 Apr;9(4):1197-203. DOI:10.3892/mmr.2014.1922
[3] Ching-Shu Lai, et al. Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice. Carcinogenesis. 2007 Dec;28(12):2581-8. DOI:10.1093/carcin/bgm231 |
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