| Identification | Back Directory | [Name]
4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride | [CAS]
1177279-49-0 | [Synonyms]
Nebracetam hydrochloride
WEB 1881 FU hydrochloride
4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride | [Molecular Formula]
C12H17ClN2O | [MDL Number]
MFCD09743242 | [MOL File]
1177279-49-0.mol | [Molecular Weight]
240.729 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, protect from light, sealed storage, away from moisture | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Nebracetam hydrochloride, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca2+]i[1]. | [in vivo]
Nebracetam (10 mg/kg, p.o.) involves not only cholinergic mechanisms but also involves lymbic and hippocampal noradrenergic mechanisms[2]. | Animal Model: | Male Wistar rats weighing 200-250 g[2]. | | Dosage: | 10, 20 mg/kg. | | Administration: | P.O. (single dose). | | Result: | Able to correct this scopolamine-induced disruption of spatial cognition. |
| [References]
[1] Kitamura Y, et al. Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. Jpn J Pharmacol. 1991 Jan;55(1):177-80. DOI:10.1254/jjp.55.177
[2] Iwasaki K, et al. Effect of nebracetam on the disruption of spatial cognition in rats. Jpn J Pharmacol. 1992 Feb;58(2):117-26. DOI:10.1254/jjp.58.117 |
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