| Identification | Back Directory | [Name]
A 62198 | [CAS]
117978-26-4 | [Synonyms]
A 62198
Reaxys ID: 26144718
5-Azido-1-cyclohexyl-1,2,5-trideoxy-2-[[N-[N-(2-methyl-1-oxopropyl)-L-phenylalanyl]-L-histidyl]amino]-L-arabino-pentitol
N-[1-[[1-[(5-azido-1-cyclohexyl-3,4-dihydroxy-pentan-2-yl)carbamoyl]-2-(3H-imidazol-4-yl)ethyl]carbamoyl]-2-phenyl-ethyl]-2-methyl-propanamide | [Molecular Formula]
C30H44N8O5 | [MDL Number]
MFCD00877827 | [MOL File]
117978-26-4.mol | [Molecular Weight]
596.72 |
| Hazard Information | Back Directory | [Description]
A 62198 is a potent and selective renin inhibitor. A-62198 induced a dose-dependent fall in mean arterial blood pressure (MAP) when administered as an i.v. bolus to anesthetized, salt-depleted monkeys. It has potential as a hypotensive agent. | [Uses]
A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses[1]. | [References]
[1] Cardiovascular actions of the primate-selective renin inhibitor, A-62198 PMID:3047366 |
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