| Identification | Back Directory | [Name]
N-2-(4-bromobenzhydryloxy)ethyldimethylamine | [CAS]
118-23-0 | [Synonyms]
bromazine
Bromanautine
Bromo-Benadryl
Histabromamine
bromodiphenhydramine
Dimenhydrinate EP Impurity H
Diphenhydramine EP Impurity C
N-2-(4-bromobenzhydryloxy)ethyldimethylamine
2-benzhydryloxy-N-(bromomethyl)-N-methylethanamine
N-2-(4-bromobenzhydryloxy)ethyldimethylamine USP/EP/BP
Dimenhydrinate Impurity 8 (Dimenhydrinate EP Impurity H)
Ethanamine, 2-(4-bromophenyl)phenylmethoxy-N,N-dimethyl-
2-((4-Bromophenyl)(phenyl)methoxy)-N,N-dimethylethanamine
2-[(RS)-(4-Bromophenyl)phenylmethoxy]-N,N-dimethylethanamine
Dimenhydrinate EP Impurity HQ: What is
Dimenhydrinate EP Impurity H Q: What is the CAS Number of
Dimenhydrinate EP Impurity H | [EINECS(EC#)]
204-238-8 | [Molecular Formula]
C17H20BrNO | [MDL Number]
MFCD00865688 | [MOL File]
118-23-0.mol | [Molecular Weight]
334.25 |
| Hazard Information | Back Directory | [Originator]
Bromazine,Shanghai Lansheng
Corporation | [Uses]
Antihistaminic. | [Definition]
ChEBI: A tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies. | [Manufacturing Process]
28.1 parts of p-bromobenzhydrylbromide are heated to boiling, under reflux
and with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of
calcined sodium carbonate. The reaction product is extracted with ether and
the etheral solution washed with water and dilute hydrochloric acid. The
residue from the solution in ether [p-bromobenzhydryl(β-chloroethyl)ether].
28.1 parts of this ether are heated with 12 parts of dimethylethylamine in a
sealed tube for 4 hours at 110°C. The product of the reaction is extracted
several time with dilute hydrochloric acid. The acid solution made alkaline, in
the cold, with concentrated caustic soda solution, and the base which
separates taken up in ether. The ether extract is washed with concentrated
potassium carbonate solution, evaporated down, and the residue distilled in
vacuo. Boiling point of p-bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine
151-154°C under 0.3 mm.
p-Bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine may be used as a
hydrochloride. | [Brand name]
Ambodryl. | [Therapeutic Function]
Antihistaminic |
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