| Identification | Back Directory | [Name]
CLP257 | [CAS]
1181081-71-9 | [Synonyms]
CLP257
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)- | [Molecular Formula]
C14H14FN3O2S | [MDL Number]
MFCD28166488 | [MOL File]
1181081-71-9.mol | [Molecular Weight]
307.34 |
| Chemical Properties | Back Directory | [Boiling point ]
473.3±55.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20 mg/ml | [form ]
powder | [pka]
7.23±0.40(Predicted) | [color ]
white to yellow to light brown | [InChI]
1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7- | [InChIKey]
SKCADXVKQRCWTR-GHXNOFRVSA-N | [SMILES]
O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O |
| Hazard Information | Back Directory | [Uses]
CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture. | [Biochem/physiol Actions]
CLP257 is a selective K+-Cl? cotransporter KCC2 activator that restored impaired Cl? transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally. | [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|