| Identification | Back Directory | [Name]
N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid | [CAS]
118252-44-1 | [Synonyms]
543U76
5-DACTHF
CPVRCGLCOADOPV-ZDUSSCGKSA-N
5-Deazacyclotetrahydrofolate
11-methenyltetrahydrohomofolate
5-Deazaacyclotetrahydrofolic acid
5,11methenyltetrahydrohomofolate,5,11 methenyltetrahydrohomofolate
N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid
N-[4-[[3-[(2,4-Diamino-1,6-dihydro-6-oxopyrimidin)-5-yl]propyl]amino]benzoyl]-L-glutamic acid
N-[4-[[3-[(2,6-Diamino-1,4-dihydro-4-oxopyrimidin)-5-yl]propyl]amino]benzoyl]-L-glutamic acid
L-Glutamic acid, N-[4-[[3-(2,6-diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)propyl]amino]benzoyl]- (9CI) | [Molecular Formula]
C19H24N6O6 | [MDL Number]
MFCD25949495 | [MOL File]
118252-44-1.mol | [Molecular Weight]
432.43 |
| Hazard Information | Back Directory | [Uses]
5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent[1]. | [References]
[1] Styles, V.L. Synthesis of the penta-glutamyl derivative of N-[4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)-propyl]amino]benzoyl]-L-glutamic acid (5-DACTHF). An acyclic analogue of tetrahydrofolic acid. 1990. Journal of Heterocyclic Chemistry, 27: 1809-1813. |
|
|