| Identification | Back Directory | [Name]
Duocarmycin A | [CAS]
118292-34-5 | [Synonyms]
DC-88-A
Duocarmycin A
(7bR,8aS)-2-[(5,6,7-Trimethoxy-1H-indole-2-yl)carbonyl]-1,2,4,5,8,8aβ-hexahydro-4,7-dioxo-6-methylcyclopropa[c]pyrrolo[3,2-e]indole-6β-carboxylic acid methyl ester
Cyclopropacpyrrolo3,2-eindole-6-carboxylic acid, 1,2,4,5,6,7,8,8a-octahydro-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (6R,7bR,8aS)-
(6R,7bR,8aS)-1,2,4,5,6,7,8,8aβ-Octahydro-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indol-2-ylcarbonyl)cyclopropa[c]pyrrolo[3,2-e]indole-6β-carboxylic acid methyl ester | [Molecular Formula]
C26H25N3O8 | [MDL Number]
MFCD00870416 | [MOL File]
118292-34-5.mol | [Molecular Weight]
507.49 |
| Hazard Information | Back Directory | [Uses]
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1]. | [IC 50]
Procaspase-3; Caspase-9; Duocarmycins | [storage]
Store at -20°C | [References]
[1] Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96. DOI:10.1016/j.biocel.2007.01.019 |
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