| Identification | Back Directory | [Name]
2-AMINO-THIAZOLE-4-CARBOXYLAMIDE
| [CAS]
118452-02-1 | [Synonyms]
2-aminothiazole-4-carboxamide
2-Amino-4-thiazolecarboxamide
4-Thiazolecarboxamide, 2-amino-
2-Amino-1,3-thiazole-4-carboamide
2-amino-1,3-thiazole-4-carboxamide
4-Thiazolecarboxamide,2-amino-(9CI)
2-Aminothiazole-4-carboxamide (~15% Inorganics)
2-AMINOTHIAZOLE-4-CARBOXAMIDE,PURITY:97% MIN(HPLC) | [Molecular Formula]
C4H5N3OS | [MDL Number]
MFCD08689593 | [MOL File]
118452-02-1.mol | [Molecular Weight]
143.17 |
| Chemical Properties | Back Directory | [Melting point ]
>195°C (dec.) | [Boiling point ]
460.3±18.0 °C(Predicted) | [density ]
1.537±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
DMSO (Slightly, Sonicated), Methanol (Slightly) | [form ]
Solid | [pka]
15.14±0.50(Predicted) | [color ]
Pale Beige |
| Hazard Information | Back Directory | [Uses]
2-Aminothiazole-4-carboxamide is a useful intermediate for organic synthesis and other chemical processes. | [Synthesis]
General procedure for the synthesis of 2-aminothiazole-4-carboxylic acid from ethyl 2-aminothiazole-4-carboxylate: 3.0 g of ethyl 2-aminothiazole-4-carboxylate was dissolved in 100 mL of ammonia, and the reaction was stirred for 2 hours at room temperature. Upon completion of the reaction, the reaction solution was concentrated to dryness and left to precipitate needle-like crystals. The crystals were collected by filtration and washed several times with cold water to remove impurities. Finally, the product was dried at room temperature to give 1.9 g of 2-aminothiazole-4-carboxamide in 76% yield with a melting point of 208-211 °C. | [References]
[1] Patent: EP2039686, 2009, A1. Location in patent: Page/Page column 23
[2] Patent: US2010/87448, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: US2006/63814, 2006, A1. Location in patent: Page/Page column 62 |
|
|