| Identification | Back Directory | [Name]
MYELIN BASIC PROTEIN (87-99) (HUMAN, BOVINE, RAT) | [CAS]
118506-26-6 | [Synonyms]
VHFFKNIVTPRTP
MBP (87-99) HUMAN
MBP (HUMAN, BOVINE, RAT)
Myelin Basic Protein (87-99)
MYELIN BASIC PROTEIN MBP (87-99), HUMAN
MYELIN BASIC PROTEIN (87-99), GUINEA PIG, HUMAN
MYELIN BASIC PROTEIN (87-99) (HUMAN, BOVINE, RAT)
VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-PRO
H-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-PRO-OH
H-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-PRO-OH (HUMAN, BOVINE, RAT)
L-Proline, L-valyl-L-histidyl-L-phenylalanyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-isoleucyl-L-valyl-L-threonyl-L-prolyl-L-arginyl-L-threonyl- | [Molecular Formula]
C74H114N20O17 | [MDL Number]
MFCD00237186 | [MOL File]
118506-26-6.mol | [Molecular Weight]
1555.82 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
≥15.97 mg/mL in EtOH with gentle warming and ultrasonic; ≥50.7 mg/mL in H2O; ≥77.8 mg/mL in DMSO | [form ]
solid | [pka]
3.39±0.20(Predicted) | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro |
| Hazard Information | Back Directory | [Uses]
Myelin Basic Protein(87-99) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein(87-99) causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS)[1][2]. | [storage]
Store at -20°C | [References]
[1] R E Jones, et al. The synthetic 87-99 peptide of myelin basic protein is encephalitogenic in Buffalo rats. J Neuroimmunol. 1992 Apr;37(3):203-12. DOI:10.1016/0165-5728(92)90004-5
[2] George Deraos, et al. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease. J Med Chem. 2008 Dec 25;51(24):7834-42. DOI:10.1021/jm800891n |
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