| Identification | Back Directory | [Name]
DPPE FUMARATE | [CAS]
1185241-83-1 | [Synonyms]
DPPE FUMARATE
Tesmilifene fumarate
N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]ETHANAMINE FUMARATE | [Molecular Formula]
C30H28O4P2 | [MDL Number]
MFCD00673908 | [MOL File]
1185241-83-1.mol | [Molecular Weight]
514.49 |
| Hazard Information | Back Directory | [Uses]
Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2]. | [Biological Activity]
Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor.? An inhibitor of histamine binding at the intracellular histamine (H lc ) site. | [in vivo]
Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2]. | Animal Model: | Male BKTO mice (25-45 g)[2]. | | Dosage: | 20 mg/kg (s.c.) and 20 μg (icv in 5 μL). | | Administration: | S.C. and icv. | | Result: | Potentiated seizures induced by both convulsants. |
| [storage]
Desiccate at -20°C | [References]
[1] Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31. DOI:10.1016/j.mehy.2005.11.005
[2] G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9. DOI:10.1007/BF02007771 |
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