| Identification | Back Directory | [Name]
1H-Pyrazole-1-acetamide, N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]- | [CAS]
1185329-96-7 | [Synonyms]
IXA4
N-[1-({methyl[2-(4-methylphenoxy)ethyl]carbamoy l}methyl)-1H-pyrazol-4-yl]-3-phenoxypropanamide
1H-Pyrazole-1-acetamide, N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-
endoplasmic reticulum (ER) proteostasis,UPR,protein secretion,Inhibitor,Inositol requiring enzyme 1,IXA4,IXA-4,IRE1,unfolded protein response,IXA 4,inhibit | [Molecular Formula]
C24H28N4O4 | [MDL Number]
MFCD13023943 | [MOL File]
1185329-96-7.mol | [Molecular Weight]
436.5 |
| Chemical Properties | Back Directory | [Boiling point ]
695.2±55.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (229.10 mM; Need ultrasonic) | [form ]
A solid | [pka]
13.84±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response). IXA4 reduces secretion of APP through IRE1 activation[1]. | [Biological Activity]
IXA4 is a nontoxicpotent and highly selective IRE1-XBP1s signaling activator th at induce ER proteostasis remodeling. IXA4 reduced Aβ levels and prevents APP-associated mitochondrial dysfunction in CHO7PA2 cells expressing the V717F APP (APPV717F) mutant. | [References]
[1] Grandjean JMD, et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nat Chem Biol. 2020;16(10):1052-1061. DOI:10.1038/s41589-020-0584-z |
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DC Chemicals
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www.chemicalbook.com/showsupplierproductslist927327/0.htm |
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