| Identification | Back Directory | [Name]
Ethanone, 1-[3'-[1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]- | [CAS]
1185410-60-9 | [Synonyms]
LRH1 Inhibitor 3
LRH-1 Inhibitor-3
LRH-1-Inhibitor-3
LRH 1 Inhibitor 3
Ethanone, 1-[3'-[1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]- | [Molecular Formula]
C23H25N3O2 | [MDL Number]
MFCD30140203 | [MOL File]
1185410-60-9.mol | [Molecular Weight]
375.46 |
| Chemical Properties | Back Directory | [Boiling point ]
578.4±50.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL | [form ]
solid | [pka]
6?+-.0.10(Predicted) | [color ]
pale yellow |
| Hazard Information | Back Directory | [Description]
LRH-1 Inhibitor-3 is the first small molecule antagonist of LRH-1 activity. | [Uses]
LRH-1 Inhibitor-3 is a small molecule that inhibits LRH-1 transcriptional activity, thereby decreasing the expression of target genes associated with cell growth and proliferation. LRH-1 Inhibitor-3 has shown potential in reducing cancer cell proliferation in human pancreatic, colon, and breast adenocarcinoma cell lines. LRH-1 Inhibitor-3 serves as a molecular probe for investigating the role of LRH-1 in various malignancies. | [Definition]
ChEBI: 1-(3'-{1-[2-(morpholin-4-yl)ethyl]pyrazol-3-yl}[1,1'-biphenyl]-3-yl)ethan-1-one is a member of the class of pyrazoles 1-[2-(morpholin-4-yl)ethyl]pyrazole carrying an additional 3'-acetyl-1,1'-biphenyl-3-yl group at position 3. An antagonist at LRH-1. It has a role as a LRH-1 antagonist. It is a member of pyrazoles, a member of morpholines, a methyl ketone, a ring assembly and an aromatic ketone. | [References]
[1] Structure-based discovery of antagonists of nuclear receptor LRH-1 DOI:10.1074/jbc.M112.411686 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|