| Identification | Back Directory | [Name]
DBPR108 | [CAS]
1186426-66-3 | [Synonyms]
DBPR108
CS-1591
DBPR-108;DBPR 108
2-Pyrrolidinecarbonitrile, 1-[2-[[1,1-dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl]amino]acetyl]-4-fluoro-, (2S,4S)- | [Molecular Formula]
C16H25FN4O2 | [MOL File]
1186426-66-3.mol | [Molecular Weight]
324.39 |
| Chemical Properties | Back Directory | [Boiling point ]
557.9±50.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 25 mg/mL (77.07 mM) | [form ]
Solid | [pka]
7.63±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.
IC50 value: 15 nM [1]
Target: DPP4 inhibitor
DBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes
mellitus. | [storage]
Store at -20°C | [References]
[1] Yeh TK, et al. (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun DOI:10.1016/j.bmcl.2010.04.124 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|