| Identification | Back Directory | [Name]
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- | [CAS]
1186654-00-1 | [Synonyms]
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- | [Molecular Formula]
C18H18F2N2O6S2 | [MOL File]
1186654-00-1.mol | [Molecular Weight]
460.47 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
powder | [color ]
white | [InChI]
1S/C18H18F2N2O6S2/c19-14-2-1-3-15(20)18(14)30(25,26)22-8-6-21(7-9-22)29(23,24)13-4-5-16-17(12-13)28-11-10-27-16/h1-5,12H,6-11H2 | [InChIKey]
SHWNKRPMUBFWKE-UHFFFAOYSA-N | [SMILES]
FC(C=CC=C1F)=C1S(N2CCN(S(C3=CC4=C(OCCO4)C=C3)(=O)=O)CC2)(=O)=O |
| Hazard Information | Back Directory | [Uses]
A cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death. | [Definition]
ChEBI: 1-(2,6-difluorophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine is a sulfonamide. |
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| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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