| Identification | Back Directory | [Name]
Acetic acid, 2-[(3-cyano-4,6-diphenyl-2-pyridinyl)oxy]-, ethyl ester | [CAS]
118666-03-8 | [Synonyms]
HTS07545
Acetic acid, 2-[(3-cyano-4,6-diphenyl-2-pyridinyl)oxy]-, ethyl ester | [Molecular Formula]
C22H18N2O3 | [MOL File]
118666-03-8.mol | [Molecular Weight]
358.39 |
| Chemical Properties | Back Directory | [Melting point ]
136-137 °C | [Boiling point ]
513.3±50.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-0.98±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HTS07545 is a potent sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 decrease the rate of breakdown of hydrogen sulfide (H2S). HTS07545 can be used for heart failure research[1]. | [References]
[1] Simon D P Baugh, et al. Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. Bioorg Med Chem Lett. 2021 Dec 15;54:128443. DOI:10.1016/j.bmcl.2021.128443 |
|
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|