| Identification | Back Directory | [Name]
Omidenepag | [CAS]
1187451-41-7 | [Synonyms]
Omidenepag
Glycine, N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]-2-pyridinyl]- | [Molecular Formula]
C23H22N6O4S | [MDL Number]
MFCD30533441 | [MOL File]
1187451-41-7.mol | [Molecular Weight]
478.52 |
| Chemical Properties | Back Directory | [Boiling point ]
769.4±70.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
3.38±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Omidenepag, is a novel selective, non-prostanoid EP2 receptor agonist for the treatment of Glaucoma: | [IC 50]
hEP4: 5480 nM (IC50); hEP2: 10 nM (IC50); hEP2: 1.1 nM (EC50) | [References]
[1] RYO IWAMURA*. Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl[J]. Journal of Medicinal Chemistry, 2018, 61 15: 6869-6891. DOI: 10.1021/acs.jmedchem.8b00808 |
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