| Identification | Back Directory | [Name]
Ralinepag | [CAS]
1187856-49-0 | [Synonyms]
APD811
APD-811
APD 811
Ralinepag
Sapanisertib
APD811;APD-811;APD 811;RALINEPAG
2-(((1R,4R)-4-((((4-CHLOROPHENYL)(PHENYL)CARBAMOYL)OXY)METHYL)CYCLOHEXYL)METHOXY)ACETIC ACID
Acetic acid, 2-[[trans-4-[[[[(4-chlorophenyl)phenylamino]carbonyl]oxy]methyl]cyclohexyl]methoxy]- | [Molecular Formula]
C23H26ClNO5 | [MOL File]
1187856-49-0.mol | [Molecular Weight]
431.91 |
| Chemical Properties | Back Directory | [Boiling point ]
609.086±35.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.257±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 15mg/mL; DMF:PBS (pH 7.2) (1:8): 0.11mg/mL; DMSO: 10mg/mL; Ethanol: 10mg/mL | [form ]
A solid | [pka]
3.504±0.10(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Ralinepag, is a potent non-prostanoid prostacyclin receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively. | [in vivo]
Ralinepag (30 mg/kg, p.o.) markedly reduces the monocrotaline (MCT)-induced increase in pulmonary arterial pressure and pulmonary vessel wall thickness in rats[1]. | [IC 50]
hIP: 8.5 nM (EC50); rIP: 530 nM (EC50); hDP1: 850 nM (EC50) | [storage]
Store at -20°C |
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| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
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