| Identification | Back Directory | [Name]
Duloxetine-d3 hydrochloride | [CAS]
1188266-11-6 | [Synonyms]
rac-Duloxetine-d3 HCl
Duloxetine-d3 hydrochloride
rac-Duloxetine-d3 Hydrochloride | [Molecular Formula]
C18H20ClNOS | [MOL File]
1188266-11-6.mol | [Molecular Weight]
333.87 |
| Hazard Information | Back Directory | [Description]
Duloxetine-d3 is intended for use as an internal standard for the quantification of duloxetine by GC- or LC-MS. (S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes). It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 μg/kg, respectively). It also decreases immobility time and increases latency to first immobility in the forced swim test in mice when administered at doses of 16 and 32 mg/kg. Formulations containing (S)-duloxetine have been used in the treatment of major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia. | [storage]
Store at 4°C | [References]
[1] DAVID T. WONG PH.D. LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake[J]. Neuropsychopharmacology, 1993, 8 1: 23-33. DOI: 10.1038/npp.1993.4
[2] K KASAMO C D M P Blier. Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 1: 278-286.
[3] VINCENT CASTAGNé Paul M Roger D Porsolt. Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse[J]. European journal of pharmacology, 2009, 616 1: Pages 128-133. DOI: 10.1016/j.ejphar.2009.06.018 |
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