| Identification | Back Directory | [Name]
NIFEDIPINE-D6 | [CAS]
1188266-14-9 | [Synonyms]
Anifed-d6
Adalate-d6
Aldipin-d6
Aldipine-d6
Cardiate-d6
NIFEDIPINE-D6
1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid dimethyl Ester-d6 | [Molecular Formula]
C17H12D6N2O6 | [MDL Number]
MFCD08063477 | [MOL File]
1188266-14-9.mol | [Molecular Weight]
352.37 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
164-165°C | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
Labeled Nifedipine, intended for use as an internal standard for the quantification of Nifedipine by GC- or LC-mass spectrometry. | [Uses]
Used as an antihypertensive and antianginal. A labelled dihydorpyridine calcium channel blocker | [Description]
Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM. Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats when administered at a dose of 10 μg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina. | [References]
[1] MERHAN RAGY Eman E. The role of nitric oxide and L-type calcium channel blocker in the contractility of rabbit ileum in vitro.[J]. Journal of physiology and biochemistry, 2012: 521-528. DOI: 10.1007/s13105-012-0167-x
[2] SUBHENDU MUKHERJEE. Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine.[J]. American Journal of Respiratory Cell and Molecular Biology, 2015, 53 4: 450-458. DOI: 10.1165/rcmb.2015-0009oc
[3] SHIZUKA ARITOMI Michihiro Y Tomoyuki Konda. L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action.[J]. Heart and Vessels, 2012, 27 4: 419-423. DOI: 10.1007/s00380-011-0191-8 |
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