| Identification | Back Directory | [Name]
ANTI-INFLAMMATORY PEPTIDE 1 | [CAS]
118850-71-8 | [Synonyms]
MQMKKVLDS
PEPTIDE 1
AF-1【peptide】
ANTIFLAMMIN-I
Antiflammin-1
antiflamminp1
ANTIFLAMMIN P I
ANTI-INFLAMMATORY PEPTIDE 1
MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER
H-MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER-OH
Anti-InflaMMatory Peptide 1
AntiflaMMin-1
ANTIFLAMMIN-I (ANTIFLAMMIN P I) SYNTHETI C >99%
L-Met-L-Gln-L-Met-L-Lys-L-Lys-L-Val-L-Leu-L-Asp-L-Ser-OH
Anti-inflammatory peptide1, Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser
Anti-Inflammatory Peptide 1 H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH
L-Serine, L-methionyl-L-glutaminyl-L-methionyl-L-lysyl-L-lysyl-L-valyl-L-leucyl-L-α-aspartyl- | [Molecular Formula]
C45H82N12O14S2 | [MDL Number]
MFCD00076844 | [MOL File]
118850-71-8.mol | [Molecular Weight]
1079.33 |
| Chemical Properties | Back Directory | [Boiling point ]
1490.7±65.0 °C(Predicted) | [density ]
1.270±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
≥107.9 mg/mL in DMSO; insoluble in EtOH; ≥21.13 mg/mL in H2O | [form ]
Lyophilized powder | [pka]
2.85±0.10(Predicted) | [Sequence]
H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH |
| Hazard Information | Back Directory | [Uses]
Antiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). Antiflammin-1 is a derivative of uteroglobin. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin (HY-108345)-induced lung injury[1][2][3]. | [in vivo]
Antiflammin-1 (2-10 mg/kg, ip, daily, for 6 days) decreases the levels of TNF-α and IL-1β in bleomycin-treated mice. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin-induced lung injury[1]. | [IC 50]
IL-1β | [storage]
Store at -20°C | [References]
[1] Liu W, et al. Antiflammin-1 attenuates bleomycin-induced pulmonary fibrosis in mice. Respir Res. 2013 Oct 8;14(1):101. DOI:10.1186/1465-9921-14-101
[2] Camussi G, et al. Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. J Exp Med. 1990 Mar 1;171(3):913-27. DOI:10.1084/jem.171.3.913
[3] Martínez Leo EE, et al. Biopeptides with antioxidant and anti-inflammatory potential in the prevention and treatment of diabesity disease. Biomed Pharmacother. 2016 Oct;83:816-826. DOI:10.1016/j.biopha.2016.07.051 |
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