| Identification | Back Directory | [Name]
Amodiaquine-d10 | [CAS]
1189449-70-4 | [Synonyms]
Miaquin-d10
CaMoquin-d10
NSC 13453-10
CaMochin-d10
CaMoquine-d10
Flavoquine-d10
CaMoquinal-d10
Amodiaquine-d10
4-[(7-Chloro-4-quinolyl)aMino]-α-(diethylaMino-d10)-o-cresol
Phenol, 4-[(7-chloro-4-quinolinyl)aMino]-2-[(diethylaMino-d10)Methyl]-
Amodiaquine D10Q: What is
Amodiaquine D10 Q: What is the CAS Number of
Amodiaquine D10 Q: What is the storage condition of
Amodiaquine D10 Q: What are the applications of
Amodiaquine D10 | [Molecular Formula]
C20H22ClN3O | [MDL Number]
MFCD09839934 | [MOL File]
1189449-70-4.mol | [Molecular Weight]
355.861 |
| Chemical Properties | Back Directory | [Melting point ]
194-198°C | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Light Yellow |
| Hazard Information | Back Directory | [Description]
Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine . It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection. | [Chemical Properties]
Pale Yellow Solid | [Uses]
An antimalarial. | [IC 50]
Plasmodium | [References]
[1] S T MARIGA. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.[J]. Antimicrobial Agents and Chemotherapy, 2004, 48 11: 4089-4096. DOI: 10.1128/aac.48.11.4089-4096.2004
[2] JULIANA M Sá T E W Jason L Chong. Malaria drug resistance: new observations and developments.[J]. Essays in biochemistry, 2011, 51: 137-160. DOI: 10.1042/bse0510137
[3] R. JACOBS W C D Alling. AN EVALUATION OF ANTIMALARIAL COMBINATIONS AGAINST PLASMODIUM BERGHEI IN THE MOUSE.[J]. Kisaengch’unghak chapchi. The Korean journal of parasitology, 1963, 11 1: 920-925. DOI: 10.2307/3275719 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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