| Identification | Back Directory | [Name]
DKYWVDODHFEZIM-KQORAOOSSA-N | [CAS]
1189508-77-7 | [Synonyms]
[13C,2H3]- (±)-Ketoprofen
DKYWVDODHFEZIM-KQORAOOSSA-N | [Molecular Formula]
C16H11D3O3 | [MDL Number]
MFCD09840824 | [MOL File]
1189508-77-7.mol | [Molecular Weight]
258.29 |
| Chemical Properties | Back Directory | [density ]
1.198±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
Ketoprofen-13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1]. | [Definition]
ChEBI: Ketoprofen is an oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2. It has a role as a non-steroidal anti-inflammatory drug, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an environmental contaminant, a xenobiotic and a drug allergen. It is a member of benzophenones and an oxo monocarboxylic acid. It is functionally related to a propionic acid. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. DOI:10.1080/02688697.2018.1500521
[2] Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. DOI:10.1016/s0960-894x(01)00800-9 |
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| Company Name: |
Energy Chemical
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| Tel: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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