| Identification | Back Directory | [Name]
FUMITREMORGIN C | [CAS]
118974-02-0 | [Synonyms]
12α-Fumitremorgin C
12alpha-Fumitremorgin C
FuMitreMorgin CFuMitreMorg
Fumitremorgin C, from Aspergillus fumigatus
Fumitremorgin C, 98%, from Aspergillus fumigatus
Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem
(5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
5H,14H-Pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione,1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-,(5aS,12S,14aS)- | [Molecular Formula]
C22H25N3O3 | [MDL Number]
MFCD08702652 | [MOL File]
118974-02-0.mol | [Molecular Weight]
379.45 |
| Chemical Properties | Back Directory | [Melting point ]
259.5-260.5℃ | [Boiling point ]
642.9±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
acetonitrile: 5 mg/mL, soluble
| [form ]
solid
| [pka]
17.16±0.40(Predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Uses]
Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has determined fumitremorgin C as a potent inhibitor of the breast cancer resistance protein BCRP/ABCG2
multidrug transporter. | [Definition]
ChEBI: An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi. A potent and specific inhibitor of the breast cancer resistance protein multidrug transporter. | [General Description]
A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent. | [Biochem/physiol Actions]
Cell permeable: yes | [target]
Antifection | P-gp | [storage]
+4°C |
|
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