| Identification | Back Directory | [Name]
Tyramine-d4 Hydrochloride | [CAS]
1189884-47-6 | [Synonyms]
Mydrial-d4
Tyramine-d4 Hydrochloride
Tyrosamine-d4 Hydrochloride
2-(4-Hydroxyphenyl)ethyl--d4-aMine HCl
4-(2-Aminoethyl-d4)phenol Hydrochloride
2-(4-Hydroxyphenyl)ethyl-1,1,2,2-d4-amine Hydrochloride | [Molecular Formula]
C8H8D4ClNO | [MDL Number]
MFCD08704875 | [MOL File]
1189884-47-6.mol | [Molecular Weight]
177.665 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
266-2680C | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: slightly soluble; Methanol: slightly soluble; Water: slightly soluble | [form ]
A solid | [color ]
White to off-white | [CAS Number Unlabeled]
60-19-5 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Adrenergic | [Description]
Tyramine-d4 is intended for use as an internal standard for the quantification of tyramine by GC- or LC-MS. Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist. It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 μM for rat, mouse, and human-rat chimera receptors, respectively). Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively). | [References]
[1] E A REESE. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 321 1: 178-186. DOI: 10.1124/jpet.106.115402
[2] R ZUCCHI. Trace amine-associated receptors and their ligands[J]. British Journal of Pharmacology, 2009, 149 8: 967-978. DOI: 10.1038/sj.bjp.0706948
[3] JANET J MAGUIRE. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.[J]. Pharmacological Reviews, 2009, 61 1: 1-8. DOI: 10.1124/pr.109.001107
[4] R B ROTHMAN. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.[J]. Synapse, 2001, 39 1: 32-41. DOI: 10.1002/1098-2396(20010101)39:1<32::aid-syn5>3.0.co;2-3 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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