| Identification | Back Directory | [Name]
TELMISARTAN-D3 | [CAS]
1189889-44-8 | [Synonyms]
Pritor-d3
Micardis-d3
BIBR 277-d3
BIBR 277SE-d3
TELMISARTAN-D3
4'-[(1,4'-DiMethyl-2'-propyl[2,6'-bi-H-benziMidazol]-1'-yl)Methyl][1,1'-biphenyl]-2-carboxylic Acid-d3
4'-[[4-Methyl-6-(1-Methyl-2-benziMidazolyl)-2-propyl-1-benziMidazolyl]
Methyl]-2-biphenylcarboxylic Acid-d3 | [Molecular Formula]
C33H27D3N4O2 | [MDL Number]
MFCD08063575 | [MOL File]
1189889-44-8.mol | [Molecular Weight]
517.64 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Crystalline Solid | [Melting point ]
262-265°C | [storage temp. ]
-20?C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
White to Beige |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Crystalline Solid | [Uses]
Labeled Telmisartan, intended for use as an internal standard for the quantification of Telmisartan by GC- or LC-mass spectrometry. | [Uses]
Labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist. | [Uses]
Labelled Telmisartan, an angiotensin II receptor antagonist | [Description]
Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM). It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (; EC50 = 4.5 μM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis. | [References]
[1] W. WIENEN. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277[J]. British Journal of Pharmacology, 1993, 110 1: 245-252. DOI: 10.1111/j.1476-5381.1993.tb13800.x
[2] STEPHEN C BENSON. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.[J]. Hypertension, 2004, 43 5: 993-1002. DOI: 10.1161/01.hyp.0000123072.34629.57
[3] ARONOW W S. Telmisartan[J]. Drugs, 2012, 56 1: 1045. DOI: 10.2165/00003495-199856060-00009
[4] JUGDUTT B I. Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderly.[J]. Clinical Interventions in Aging, 2010, 5: 403-416. DOI: 10.2147/cia.s6709
[5] ROLAND E SCHMIEDER Matthew R W George Bakris. Telmisartan in incipient and overt diabetic renal disease.[J]. Journal of Nephrology, 2011, 24 3: 263-273. DOI: 10.5301/jn.2011.6416 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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