| Identification | Back Directory | [Name]
(4-BroMobutyl)phosphonic acid | [CAS]
1190-14-3 | [Synonyms]
(4-BroMobutyl)phosphonic acid
Phosphonic acid, (4-bromobutyl)- (6CI,7CI,9CI) | [Molecular Formula]
C4H10BrO3P | [MDL Number]
MFCD00466589 | [MOL File]
1190-14-3.mol | [Molecular Weight]
216.998 |
| Chemical Properties | Back Directory | [Melting point ]
127.0 to 131.0 °C | [Boiling point ]
358.8±44.0 °C(Predicted) | [density ]
1.709±0.06 g/cm3(Predicted) | [form ]
powder to crystal | [pka]
2.52±0.10(Predicted) | [color ]
White to Almost white |
| Hazard Information | Back Directory | [Description]
4-bromobutylphosphonic acid contains a bromine group and a phosphonic acid group. The bromine is a good leaving group. The hydrophilic properties of the PEG linkers increase the water solubility of the compound in aqueous media. | [Uses]
4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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