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1190089-70-3

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1190089-70-3 Structure

1190089-70-3 Structure
IdentificationBack Directory
[Name]

2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite
[CAS]

1190089-70-3
[Synonyms]

2'-F-2'-ara-dU Phosphoramidite
2'-F-dU-ANA-CE Phosphoramidite
2'-ara-2'-F-2'-dU Phosphoramidite
2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite
5'-O-DMT-2'-F-2'-arabinofuranosyl-deoxyuridine 3'-CE phosphoramidite
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro--D-arabinouridine-3'-CED-phosphoramidite
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro--D-arabinouridine-3'-CEN-phosphoramidite
5’-O-(4,4’-Dimethoxytrityl)-2’-deoxy-2’-fluoro-b-D-arabinouridine-3’-CED-phosphoramidite
2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-
[Molecular Formula]

C39H46FN4O8P
[MDL Number]

MFCD15145421
[MOL File]

1190089-70-3.mol
[Molecular Weight]

748.79
Chemical PropertiesBack Directory
[solubility ]

DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
[pka]

9.39±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents[1].
[References]

[1] Connolly GP, et al. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. 1999 May;20(5):218-25. DOI:10.1016/s0165-6147(99)01298-5
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