| Identification | Back Directory | [Name]
GanoMycin I | [CAS]
1191255-15-8 | [Synonyms]
GanoMycin I
2(5H)-Furanone, 5-(2,5-dihydroxyphenyl)-3-[(3E)-4,8-dimethyl-3,7-nonadien-1-yl]-, (5R)- | [Molecular Formula]
C21H26O4 | [MDL Number]
MFCD32645025 | [MOL File]
1191255-15-8.mol | [Molecular Weight]
342.43 |
| Hazard Information | Back Directory | [Uses]
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects[1][2]. | [References]
[1] Tran PT, et, al. Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1. Phytomedicine. 2019 Mar 1;55:1-8. DOI:10.1016/j.phymed.2018.10.029
[2] Wang K, et, al. Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo. J Med Chem. 2018 Apr 26;61(8):3609-3625. DOI:10.1021/acs.jmedchem.8b00107 |
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