| Identification | Back Directory | [Name]
3-[1-[(S)-3-Hydroxy-3-cyclohexylpropyl]-3α,4-dimethylpiperidine-4α-yl]phenol | [CAS]
119193-09-8 | [Synonyms]
LY-255582
LY255582 >=98% (HPLC)
3-[1-[(S)-3-Hydroxy-3-cyclohexylpropyl]-3α,4-dimethylpiperidine-4α-yl]phenol
3-[1-[(S)-3-Hydroxy-3-cyclohexylpropyl]-3α,4-dimethylpiperidine-4α-yl]phenol
(aS,3R,4R)-a-Cyclohexyl-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinepropanol
1-Piperidinepropanol, α-cyclohexyl-4-(3-hydroxyphenyl)-3,4-dimethyl-, (αS,3R,4R)-
(+)-3-[(3R,4R)-1-[(S)-3-Hydroxy-3-cyclohexylpropyl]-3,4-dimethylpiperidin-4-yl]phenol
(3R,4R)-3,4-Dimethyl-1-[(3S)-3-hydroxy-3-cyclohexyl-propyl]-4-(3-hydroxyphenyl)piperidine | [Molecular Formula]
C22H35NO2 | [MDL Number]
MFCD00878181 | [MOL File]
119193-09-8.mol | [Molecular Weight]
345.52 |
| Chemical Properties | Back Directory | [Melting point ]
154-155 °C | [Boiling point ]
502.3±50.0 °C(Predicted) | [density ]
1.045±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
9.96±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
LY255582 may be used in opioid receptor-mediated cell signaling studies. | [Biological Activity]
LY255582 inhibits the diet-associated increases in mesolimbic dopamine levels and reduces the consumption of highly-palatable food intake.''LY255582 is a centrally active opioid receptor antagonist (defined as an inverse agonist in 2011 JPET paper) th at inhibited weight gain in obese Zucker rats over 30 days. It is more th at 5-fold selective for mu opioid receptor compared to kappa opioid receptors and 13-fold selective over delta opioid receptors. | [in vivo]
LY255582 (100 μg, i.c.v.) reduced food intake in rats[1].
LY255582 (15 mg/kg, s.c., once daily) decreases food intake and body weight gain of fed obese Zucker rats[4].
| Animal Model: | STZ-induced diabetic mice[1] | | Dosage: | 100, 10 and 1 μg | | Administration: | i.c.v. | | Result: | Decreased food at 100, 10 and 1 μg by 76, 62 and 29%. |
| [IC 50]
μ Opioid Receptor/MOR: 0.4 nM (Ki); δ Opioid Receptor/DOR: 5.2 nM (Ki); κ Opioid Receptor/KOR: 2.0 nM (Ki) |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|