| Identification | Back Directory | [Name]
PE 154 | [CAS]
1192750-33-6 | [Synonyms]
PE 154
(E)-2-(4-(((7-(Diethylamino)-2,4-dioxochroman-3-ylidene)methyl)amino)phenyl)-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide
4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide
2-(1,2,3,4-Tetrahydro-9-acridinyl)hydrazide-4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid
Benzeneacetic acid, 4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-, 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide | [Molecular Formula]
C35H35N5O4 | [MOL File]
1192750-33-6.mol | [Molecular Weight]
589.68 |
| Hazard Information | Back Directory | [Uses]
PE 154 is a potent and fluorescent inhibitor of human acetylcholinesterase | [in vivo]
PE154 (hippocampus injection; 0.2 μg per mouse; once) can stain the histochemical of cortical βamyloid plaques[2]. | Animal Model: | 13–20-month-old triple-transgenic mice harbouring three mutant genes (APPswe, PS-1 and tauP301L)[2] | | Dosage: | 0.2 μg per mouse | | Administration: | Hippocampus injection; 0.2 μg per mouse; once | | Result: | Showed the histochemical staining of cortical βamyloid plaques in triple-transgenic (TTG) mice. |
| [IC 50]
BChE: 16 nM (IC50); AChE: 280 pM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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