ChemicalBook--->CAS DataBase List--->1192810-88-0

1192810-88-0

1192810-88-0 Structure

1192810-88-0 Structure
IdentificationBack Directory
[Name]

(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE
[CAS]

1192810-88-0
[Synonyms]

(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE
[Molecular Formula]

C18H20N4O
[MDL Number]

MFCD30828959
[MOL File]

1192810-88-0.mol
[Molecular Weight]

308.39
Chemical PropertiesBack Directory
[Boiling point ]

492.3±55.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[pka]

11.06±0.40(Predicted)
Hazard InformationBack Directory
[Description]

BMS-902483 is a potent α7 partial agonist, which improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm. Preclinical and early clinical data suggest that α7 nicotinic acetylcholine receptor (nAChR) agonists have potential for the treatment of cognitive and negative symptoms in schizophrenia patients
[Uses]

BMS-902483 is a quinuclidine-containing spirooxazolidine that is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR). BMS-902483 improves cognitive ability in preclinical rodent models.[1].
[References]

[1] Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5, 3’-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure Activity Relationship.
1192810-88-0 suppliers list
Company Name: TargetMol Chemicals Inc.
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Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
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Company Name: Shanghai Dexuan Pharmaceutical Technology Co., Ltd  
Tel: 1701086315
Website: www.chemicalbook.com/ShowSupplierProductsList182151/0.htm
Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
Company Name: AstaTech, Inc  
Tel: (215) 785 3197
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