| Identification | Back Directory | [Name]
NITD 609 | [CAS]
1193314-23-6 | [Synonyms]
KAE609
NITD 609
Cipargamin-13C6
Cipargamin（ KAE609）
NITD609;CIPARGAMIN;KAE609
(3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methylspiro[1H-indole-3,...
KAE 609,KAE-609,inhibit,Cipargamin,NITD-609,NITD 609,Parasite,Inhibitor
(1'R,3'S)-5,7'-Dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one
(1'R,3'S)-5,7'-Dichloro-6'-fluoro-2',3',4',9'-tetrahydro-3'-methylspiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one | [Molecular Formula]
C19H14Cl2FN3O | [MOL File]
1193314-23-6.mol | [Molecular Weight]
390.24 |
| Chemical Properties | Back Directory | [Boiling point ]
621.3±55.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
DMSO: soluble | [form ]
A crystalline solid | [pka]
13.87±0.40(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
Cipargamin (NITD609) is an potent antimalarial compound, with an IC50 of appr 1 nM against P. falciparum. | [in vivo]
Cipargamin (NITD609) shows favorable pharmacokinetic properties and displays single dose cure efficacy in a malaria mouse model. Cipargamin (100 mg/kg) completely clears P. bergheiinfection in all treated mice, and partial cure (50%) is achieved with a single oral dose at 30 mg/kg[3]. | [IC 50]
Plasmodium | [storage]
Store at -20°C | [References]
[1] Zhou Y, et al. Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2014;58(3):1789-92. DOI:10.1128/AAC.02225-13
[2] van Pelt-Koops JC, et al. The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector. Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8. DOI:10.1128/AAC.06377-11
[3] Rottmann M, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80. DOI:10.1126/science.1193225 |
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| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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