| Identification | Back Directory | [Name]
U-75302 | [CAS]
119477-85-9 | [Synonyms]
U-75302
6-[6-(3-HYDROXY-1E,5Z-UNDECADIENYL)-2-PYRIDINYL]-1,5-HEXANEDIOL
6-(6-(3R-HYDROXY-1E,5Z-UNDECADIEN-1-YL)-2-PYRIDINYL)-1,5S-HEXANEDIOL
(5R)-6-[6-[(1E,3S,5Z)-3-Hydroxy-1,5-undecadienyl]-2-pyridinyl]-1,5-hexanediol
(5R)-6-[6-[(3S,2E,5Z)-3-Hydroxy-1,5-undecadienyl]-2-pyridinyl]-1,5-hexanediol
1,5-Hexanediol, 6-[6-[(1E,3R,5Z)-3-hydroxy-1,5-undecadien-1-yl]-2-pyridinyl]-, (5S)- | [Molecular Formula]
C22H35NO3 | [MDL Number]
MFCD00270915 | [MOL File]
119477-85-9.mol | [Molecular Weight]
361.52 |
| Hazard Information | Back Directory | [Description]
U-75302 is an LTB4 receptor antagonist with a Ki of 159 nM on guinea pig lung membranes. This activity is specific for the BLT1 receptor; U-75302 does not antagonize the binding of [3H]-LTB4 to the human BLT2 receptor. | [Uses]
U-75302 is a selective leukotriene B4 antagonist. | [storage]
Store at -20°C | [References]
[1] R C FALCONE D A. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents.[J]. Journal of Pharmacology and Experimental Therapeutics, 1990, 255 2: 565-571.
[2] ALICE H. LIN. Novel Molecules That Antagonize Leukotriene B4 Binding to Neutrophils[J]. Annals of the New York Academy of Sciences, 1988, 524 1: 196-200. DOI: 10.1111/j.1749-6632.1988.tb38542.x
[3] S WANG. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.[J]. The Journal of Biological Chemistry, 2000, 275 52: 40686-40694. DOI: 10.1074/jbc.m004512200
[4] SHIGEYASU TSUDA. Novel Mechanism of Regulation of the 5-lipoxygenase/leukotriene B4 Pathway by High-Density Lipoprotein in Macrophages[J]. Atherosclerosis. Supplements, 2018, 1 1. DOI: 10.1016/j.atherosclerosissup.2018.04.186 |
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