| Identification | Back Directory | [Name]
Benzoic acid, 3-(2-quinolinylmethoxy)-, methyl ester | [CAS]
119515-00-3 | [Synonyms]
Benzoic acid, 3-(2-quinolinylmethoxy)-, methyl ester | [Molecular Formula]
C18H15NO3 | [MOL File]
119515-00-3.mol | [Molecular Weight]
293.32 |
| Chemical Properties | Back Directory | [Boiling point ]
448.2±25.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [solubility ]
DMF: insol; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol | [form ]
A crystalline solid | [pka]
3.69±0.48(Predicted) |
| Hazard Information | Back Directory | [Description]
CAY10788 is an antagonist of CysLT1 receptor. | [Uses]
CysLT1 receptor antagonist-1 (Compound 4) is an antagonist for cysteinyl leukotriene receptor 1 (CysLT1R) with an IC50 of 3.9 μM. CysLT1 receptor antagonist-1 exhibits weak agonist activity against G-protein-coupled bile acid receptor 1 (GPBAR1) with an efficact of 23% at 10 μM. CysLT1 receptor antagonist-1 can be used for asthma and allergic diseases researchs[1]. | [IC 50]
CysLT1: 3.9 μM (IC50) | [References]
[1] Fiorillo B, et al., Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529. DOI:10.1021/acs.jmedchem.1c01078 |
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