| Identification | Back Directory | [Name]
Diclofenac epolamine | [CAS]
119623-66-4 | [Synonyms]
DIEP
Diclofenac epolamine
diclofenac hydroxyethylpyrrolidine
2-((2,6-Dichlorophenyl)amino)benzeneacetic acid 1-pyrrolidineethanol
2-(PYRROLIDIN-1-YL)ETHAN-1-OL 2-(2-((2,6-DICHLOROPHENYL)AMINO)PHENYL)ACETATE | [Molecular Formula]
C15H12Cl2O2.C6H13NO | [MDL Number]
MFCD11655944 | [MOL File]
119623-66-4.mol | [Molecular Weight]
410.339 |
| Chemical Properties | Back Directory | [Melting point ]
58-60°C | [storage temp. ]
Hygroscopic, Refrigerator, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly) | [form ]
Solid | [color ]
White to Pale Yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Diclofenac Epolamine is a diclofenac salt with greater water solubility and better cutaneous absorption properties than other commonly used forms of the drug. Diclofenac, a non-steroidal anti-inflammatory drugs (NSAIDs), is the mainstay of analgesic and anti-inflammatory treatment in dentistry. | [in vivo]
Flector Patch (Diclofenac epolamine) (1.3% w/w, exteral application) displays effective in treating inflammatory conditions[2]. | Animal Model: | Rat paw edema inflammation model (induced with carrageenan)[2] | | Dosage: | 1.3% w/w | | Administration: | Exteral application | | Result: | Inhibited edema and showed anti-inflammatory efficacy at 6 hours after application. |
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