| Identification | Back Directory | [Name]
Terlakiren | [CAS]
119625-78-4 | [Synonyms]
CP 80794
Terlakiren
L-Cysteinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-S-methyl-
(2R,3S)-4-Cyclohexyl-2-hydroxy-3-[(R)-3-methylthio-2-[(S)-2-(4-morpholinylcarbonylamino)-3-phenylpropanoylamino]propanoylamino]butyric acid isopropyl ester | [Molecular Formula]
C31H48N4O7S | [MDL Number]
MFCD00907627 | [MOL File]
119625-78-4.mol | [Molecular Weight]
620.8 |
| Chemical Properties | Back Directory | [Boiling point ]
908.263±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.205±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
12.439±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC50 value of 0.7 nM. Terlakiren has potential applications in hypertension[1]. | [Definition]
ChEBI: Terlakiren is a peptide. | [References]
[1] Fouda H, et al. Quantitative analysis by high-performance liquid chromatography atmospheric pressure chemical ionization mass spectrometry: The determination of the renin inhibitor CP-80,794 in human serum. J Am Soc Mass Spectrom. 1991 Apr;2(2):164-7. DOI:10.1016/1044-0305(91)80010-5 |
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