| Chemical Properties | Back Directory | [Boiling point ]
596.0±60.0 °C(Predicted) | [density ]
1.383±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.60±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
ST-1006 is a histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. | [Uses]
ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2]. | [in vivo]
ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) has anti-inflammatory effect and displays an antipruritic effect[1]. | Animal Model: | Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] | | Dosage: | 1-100 mg/kg | | Administration: | Subcutaneous injection | | Result: | Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg. |
| [IC 50]
H4 receptor: 7.94 (pKi) | [References]
[1] Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. DOI:10.1007/s00210-018-1553-x
[2] Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73. DOI:10.1111/all.12875 |
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