| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 35 mg/mL (85.38 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2]. | [in vivo]
Orally administered Endoxifen is rapidly absorbed and systemically available when tested in female rats. The Endoxifen-treated rats show 787% higher exposure (AUC0–∞) and 1,500% higher concentration (Cmax) levels of Endoxifen when compared with Tamoxifen. Oral Endoxifen administration once a day for 28 consecutive days at dosages 2, 4, and 8 mg/kg proves safe and results in progressive inhibition of the growth of the human mammary tumor xenografts in female mice[2]. | [IC 50]
Aromatase | [storage]
Store at -20°C | [References]
[1] Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236. PMID:20120835
[2] Wu X, et al. The tamoxifen metabolite, Endoxifen, is a potent antiestrogen that targets estrogen receptor alpha fordegradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7. DOI:10.1158/0008-5472.CAN-08-3933 |
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Musechem
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BOC Sciences
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https://www.bocsci.com |
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